Bromelain is known as an enzyme that is extracted from the pineapple’s fruit, juice, or stem. Studies have shown that it may help alleviate symptoms of diarrhea and other digestive problems, osteoarthritis, cardiovascular anomalies, and even cancer. 
While all medicines and supplements go through clinical studies and quality assurance before they become available in the market, there are also certain facts that you need to consider before taking them.
Patient safety and side effects. Bromelain is deemed safe when taken in appropriate, recommended doses. It can easily be absorbed via the gastrointestinal tract without losing its beneficial properties just like other supplements/medicines. However, there are some common side effects such as stomach discomforts and allergic reactions that is why it is not specifically recommended for those with a strong allergic reaction to pineapple and wheat. As a safety precaution, Bromelain is also not intended for pregnant and breastfeeding mother.
Dosage. Bromelain may be available in cream for topical use, but the more common preparation known form is via oral pills or tablets. It is safe to take a Bromelain at least 80-400 milligram twice to thrice a day or as prescribed by the doctor. 
Interactions with medications. If you are using other medicines as treatment for any other underlying illnesses, it is best to consult with a doctor or health care provider before using Bromelain. For instance, if you are taking anticoagulant or antiplatelet drugs with Bromelain, this may affect blood clotting and bleeding properties. 
IntegrAid Bromelain by Pharex is an all-natural dietary supplement that helps relieve a person of dyspeptic symptoms. For the recommended dosage and proper intake to ask your doctor about it.